Investigation of water diffusion in brain tissue under stress conditions
The proposal aims to investigate the distribution of water pools (which strongly differ in dynamical properties) across the brain tissue heterogeneity. For that, we propose a neutron scattering investigation on rat brain tissue samples, submitted to different challenges to modify cell structures and/or volumes, two potential contributors to water diffusion dynamics. In parallel to that, in order to investigate whether the results obtained on brain tissue, which represents a mixture of cell types, are the same as in more simple systems, the same study will be performed on Neuro2a (N2a) cells, a fast-growing mouse neuroblastoma cell line, often used as model for neurons.
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NATALI Francesca; BARBIER Emmanuel; CUPANE Antonio; DELHOMME Alex; GILI TOS Bastien; NALE Michaël; OLLIVIER Jacques and PIAZZA Irina. (2015). Investigation of water diffusion in brain tissue under stress conditions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-740
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