Influence of Cholera Toxin Subunit B binding on lipid membrane fluctuations
The membrane binding subunit of cholera toxin CTxB has previously been shown to strongly affect lipid membrane ordering in gel phase membranes upon binding to GM1 inducing lipid texture. We expect the structural changes observed to be accompanied by large changes in membrane dynamics upon binding as regions of the membrane become pinned by the defined geometry of the binding sites in GM1. We propose to measure using neutron spin-echo the changes in membrane fluctuation upon binding. We plan on using samples in the previously investigated (using grazing incidence X-ray) diffraction gel phase as well as in the fluid phase where investigation using GIXD is not feasible.
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Dennison, A.J.C.; Marek Bekir; FALUS Peter; HOFFMANN Ingo; Andrew J. Parnell and WATKINS Erik. (2016). Influence of Cholera Toxin Subunit B binding on lipid membrane fluctuations. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-772
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