Effect of pressure and osmolytes on the dynamics of oligomeric proteins
We plan to investigate the effect of pressure on the global and internal dynamics of two different alcohol dehydrogenases consisting of dimeric and tetrameric complexes. The results will yield novel insights how hydrostatic pressure affects the dynamics of these enzymes and how the global and internal dynamics differ between the tetrameric, the dimeric and the monomeric states, the latter being obtained after pressure-induced dissociation. Further, we plan to investigate how the dynamical properties are affected by binding of the cofactor nicotinamide adenine dinucleotide and by the presence of the compatible osmolytes, which are known to alleviate environmental pressure stress imposed on proteins.
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AL AYOUBI Samy; PETERS Judith; SCHUMMEL Paul Hendrik; SEYDEL Tilo and WINTER Roland. (2018). Effect of pressure and osmolytes on the dynamics of oligomeric proteins. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-809
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