Dynamics of intermediate states during the alpha-synuclein fibrillation process
Alpha-synuclein and Tau protein amyloid fibers constitute pathological hallmarks of Parkinson and Alzheimer diseases, respectively. Using the highest available flux and signal to noise ratio at sub-ueV energy resolution, we propose to investigate intermediate states during the fibrillation process of alpha-synuclein protein. We will correlate the results with different levels of toxicity associated with different fibrillation speeds. The proposal will also constitute a preparatory state towards a full in-situ observation of the entire process and a comparative study of the wild-type and mutants of alpha-synuclein.
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POUNOT Kevin; CHAABAN Hussein; FICHOU Yann; MARASINI Carlotta; SCHIRO Giorgio; SEYDEL Tilo and WEIK Martin. (2018). Dynamics of intermediate states during the alpha-synuclein fibrillation process. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-811
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