Proteome dynamics as a proxy for cellular thermal stability
The biophysical principles at the basis of the adaptation of life to extreme environments are still elusive. Here we propose to investigate different bacteria with psychrophile to hyperthermophile character to establish the link between the sub-nanosecond timescale dynamics of their proteome and their thermal stability. We aim at providing a novel biophysical picture of the way fast local protein motions determine the thermal stability of cellular proteome and consequently the temperature range where microbial life can thrive. In this first phase of the project, we plan to measure the dynamics of psychrophilic and mesophilic bacterial proteome at the IN13 and IN5 spectrometers.
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Alessandro Paciaroni; DI BARI Daniele; GIUDICI ORTICONI Marie Therese; GUIRAL Marianne; OLLIVIER Jacques; PACHETTI Maria; PETERS Judith and STERPONE Fabio. (2018). Proteome dynamics as a proxy for cellular thermal stability. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-839
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