Neutron spin echo spectroscopy study of nanoscale dynamics of the alpha-catenin/beta-catenin complex
Cell-cell adhesion is essential for the development, function, maintenance, and transmission of force in the tissues of higher organisms. The multidomain proteins alpha-catenin and beta-catenin are key components of the cell-cell adherens junction complex. Despite the importance of the catenin complex in the adherens junction, the mechanism by which the catenin complex connects the adherens junction to the actin cytoskeleton remains to be determined. A hypothesis is that the catenin complex is the core mechanosensor that allows cells to locally sense, transduce and adapt to environmental mechanical constraints. In our recently published results, we have shown that alpha-catenin is a flexible molecule that is suitable for neutron spin echo (NSE) study (Nicholl et al Biophys J. 2018). Our preliminary structural study indicates that the alpha-catenin/beta-catenin complex can sample different configurations. Here we will extend the study to use NSE to determine the nanoscale dynamics of the alpha-catenin/beta-catenin complex. The study will contribute to our understanding of how the catenin complex functions as a mechanosensor.
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NICHOLL Iain; Zimei Bu; CALLAWAY David and FARAGO Bela. (2019). Neutron spin echo spectroscopy study of nanoscale dynamics of the alpha-catenin/beta-catenin complex. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-852
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