In-situ investigation of the dynamics of intermediate states during insulin and tau fibrillation
Aggregation and, in particular, fibrillation of proteins are often associated with neurodegenerative diseases. The extensively studied alpha-synuclein and tau are for instance involved in Parkinson and Alzheimer, respectively. Another protein of relevance is insulin, for which amyloid deposits were found at injection sites in diabetes patients. Previous results suggest an important role of intermediate oligomeric states on the fibrillation pathway in toxicity. However, these intermediates remain elusive but of major interest. We already measured on IN16B (8-04-811) the formation of lysozyme aggregates, thereby furnishing a proof of concept to follow fibrillation kinetics in-situ using elastic and inelastic fixed window scans. We now hope to capture the dynamics of the intermediates and, thus, obtain an unprecedented information about the fibrillation pathway of insulin and tau.
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POUNOT Kevin; FODERA Vito; SCHIRO Giorgio; SEYDEL Tilo; WEIK Martin and ZALA Ninon. (2020). In-situ investigation of the dynamics of intermediate states during insulin and tau fibrillation. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-863
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