To understand the antimicrobial activity of the salivary protein Histatin 5
The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5 (His5), which acts in defence against oral candidiasis caused by Candida Albicans. Experiments and simulations have indicated the importance of the dynamic properties of the protein. Combining IN16B and IN5 quasi-elastic neutron scattering would cover a very complete dynamics range. Together with novel data analysis frameworks, separating the different hierarchical levels of dynamics, new insights not previously accessible will be allowed. Focus will be access to (sub) nanosecond internal diffusive motions of the protein in solution for a range of protein concentrations and different temperatures. The choice of focus is based on previous scattering experiments and simulations, which together would yield molecular understanding of the system of both medical and academic relevance.
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Download DataThe recommended format for citing this dataset in a research publication is in the following format:
Marie Skepö; APPEL Markus; Eric Fagerberg; LENTON Samuel; NYLANDER Tommy; OLLIVIER Jacques and SEYDEL Tilo. (2020). To understand the antimicrobial activity of the salivary protein Histatin 5. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-868
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