Global proteome dynamics as a proxy for cellular thermal stability.
The biophysical principles at the basis of the adaptation of life to extreme environments are still elusive. Here we propose to investigate different bacteria with psychrophile and mesoophile character to establish the link between the nanosecond timescale dynamics of their proteome and their thermal stability. We aim at providing a novel biophysical picture of the way fast global protein motions are related to the thermal stability of the very cellular proteome and consequently the temperature range where microbial life can thrive. The results from the spectrometer IN16B will be combined with mesoscale REST molecular dynamics simulations.
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PETERS Judith; DI BARI Daniele; GIUDICI ORTICONI Marie Therese; GUIRAL Marianne; Alessandro Paciaroni; SEYDEL Tilo and STERPONE Fabio. (2020). Global proteome dynamics as a proxy for cellular thermal stability.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-879
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