Molecular bases of protein adaptation to high hydrostatic pressure in piezophilic Archaea
The most accepted scenarios for the origin of life imply an origin near deep-sea hydrothermal vents, e.g. an origin under both high temperature and high hydrostatic pressure (HHP). Understanding the basis of these adaptations is essential to strengthen origin of life scenarios as well as understand life in the most extreme environments. To date, genomic studies have failed to identify the basis of the adaptation to HHP. Based on recent results, we propose that HHP affects only the protein-water interface, mimicking the impact of self-crowding or organic osmolytes, explaining the failure of genomic approaches. To circumvent this problem, we propose to characterize in details the physical impact of HHP on a set of piezophile proteins, in order to determine the amino acids responsible for the adaptation to HHP and reconstruct the evolutionary path to HHP adaptation. Thus, this project will yield important data for protein folding and the understanding of the origins of life.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Antonino Caliņ; DE FRANCESCO Alessio; NIDRICHE Agathe; Phil Oger and PETERS Judith. (2021). Molecular bases of protein adaptation to high hydrostatic pressure in piezophilic Archaea. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-886
This data is not yet public
This data is not yet public
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