Influence of aluminum ions and nanoparticles on the protein tau dynamics and aggregation
The protein tau is an intrinsically disordered protein of 441 amino acids in its largest form. It is involved in Alzheimer's disease and can form amyloid fibers, which consist of a stack of beta-sheets forming an elongated fiber. In addition, the amyloid deposits containing tau were also found to contain substantial amounts of aluminum. The aluminum can induce tau aggregation and can promote neurotoxicity in-vivo. While Al3+ was shown to accelerate tau aggregation in-vivo, the molecular insights, center-of-mass diffusion, internal dynamics, beta-sheets formation, are still to be studied to better understand the effect of aluminum on tau aggregation. In a previous experiment at the ILL (proposal 8-04-863), we observed a significant effect of the aluminum sample holder on protein diffusion and internal dynamics. We hereby propose to investigate the effect of Al3+ and nanoparticles of oxidized aluminum on tau aggregation using Teflon-coated sample holder. The unique energy transfer range accessible with the combination of IN15 and BATS option of IN16B will be used to accurately characterize center-of-mass diffusion and internal dynamics during tau aggregation.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
POUNOT Kevin; BECK Christian; CZAKKEL Orsolya; HOFFMANN Ingo; MATSARSKAIA Olga; SCHIRO Giorgio; Frank Schreiber; SEYDEL Tilo and WEIK Martin. (2021). Influence of aluminum ions and nanoparticles on the protein tau dynamics and aggregation. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-901
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This data is not yet public
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