DOI > 10.5291/ILL-DATA.8-04-931

This proposal is publicly available since 10/07/2026

Title

antibody domain dynamics

Abstract

We want to examine the influence of common excipients onto the domain/internal dynamics of monoclonal antibodies at lower concentrations and to identify relevant motional patterns. We will use different excipients modulating the free volume (crowding), the surface charge (zwitterionic molecules) and solvent quality which are used in common mAb drug formulations.

Experimental Report

Download Experimental Report

Download Data

Please note that you will need to login with your ILL credentials to download the data.

Download Data

Data Citation

The recommended format for citing this dataset in a research publication is in the following format:

BIEHL Ralf; CZAKKEL Orsolya; HOFFMANN Ingo; KRUTEVA Margarita; RICHTER Dieter and Andreas M. Stadler. (2021). antibody domain dynamics. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-931

Cited by

This data has not been cited by any articles.

Metadata

Experiment Parameters

  • Environment temperature

    20 degree Celsius

  • Experiment energy

    12A, 10A, 8 A

  • Experiment moment

    0.02-0.15 nm-1

Sample Parameters

  • Formula

    • protein in D2O phosphate buffer

Institut Laue-Langevin

Copyright © 2026

  • Access to data is governed by the ILL data policy.
  • ILL has partnered with DataCite as the registration agency for data persistent identifiers.