Drug release kinetics & water diffusion in a long-acting peptide hydrogel drug delivery implant for combined contraception & HIV prevention
We are developing a hydrogel implant for the combined delivery of HIV/AIDS and contraceptive drugs over a prolonged period e.g. 28 days. This implant is composed of tissue-like peptides for enhanced biocompatibility. Patients struggle to adhere to complex regimens of these medicines, which require a cocktail of drugs to be taken several times daily. Our therapy removes this need, improving adherence to medication. The objective of this project is to generate Quasi-Elastic Neutron Scattering (QENS) data using IN5 instrument to probe water diffusion within our hydrogels on the picosecond timescale in the presence of multiple model hydrophobic HIV/AIDS and contraceptive drugs. Dynamics/diffusion of water within our hydrogels are important in determining drug release kinetics. QENS data will support our rheology, microscopy, DOSY, spectroscopy and drug release and previous SANS data obtained at ILL. This will allow us to tailor diffusion within the gels to drug release kinetics for sustained 28-day delivery by modifying the chemical structure of our hydrogel forming peptide.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
LAVERTY Garry; AN Yuming; Sreekanth Pentlavalli and ZBIRI Mohamed. (2023). Drug release kinetics & water diffusion in a long-acting peptide hydrogel drug delivery implant for combined contraception & HIV prevention. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-935
This data is not yet public
This data is not yet public
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