Diffusive Dynamics of the proteome as a Proxy of Cell Death for psychrophilic and hyperthermophilic bacteria
The biophysical principles at the basis of the adaptation of life to extreme environments are still elusive. Very recently we combined Neutron Scattering (NS) spectroscopy and Molecular Dynamics (MD) simulations to show that the global motions of the ¿E. coli¿ proteome are intimately related to the cell¿s metabolism and thermal stability in the temperature range where microbial life can thrive. We aim now at applying the same approach to two bacteria with a radically different character, i.e. the psychrophilic ¿P. Articus¿ (PA) and the hyper-thermophilic ¿A. Aeolicus¿ (AA). Therefore, we propose to study the ns timescale global diffusive dynamics of the proteome of PA and AA in their temperature niche. By comparing previous results on ¿E. coli¿ with those on PA and AA, we will provide a possibly general picture on the relationship between ns timecsale proteome dynamics, thermal stability and metabolism.
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CAVIGLIA Beatrice; NAZZAL Nada; Alessandro Paciaroni; PETERS Judith; SEYDEL Tilo and STERPONE Fabio. (2023). Diffusive Dynamics of the proteome as a Proxy of Cell Death for psychrophilic and hyperthermophilic bacteria. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-960
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