Understanding bone collagen structure with Small Angle Neutron Scattering
An interest in understanding the structure-composition-mechanical function of musculoskeletal tissues has led to become frequent users of SAXS. SAXS data from bone tissue is heavily dominated by the mineral scattering, while we are highly interested in the behaviour of the collagen network, specifically its alterations in certain metabolic bone diseases. Therefore, we are looking for alternatives to SAXS. We believe that SANS will result in a different contrast between the phases in bone, and therefore better be able to answer our research questions related to bone collagen. A first pilot SANS experiment was carried out at SINQ, PSI. Although promising, the signal-to-noise ratio was not sufficient to resolve our question and determine the potential of the technique, and to address more relevant model systems of smaller animals. Thus, we now propose an experiment on rabbit bone ranging from newborn to adult bone as a representation of tissue with different mineral-collagen structure and orientation. We aim to obtain quantitative information of the collagen structure in bone. Data will be compared to SAXS data recently obtained from the same samples.
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ISAKSSON Hanna; GENTILE Luigi; LE CANN Sophie; OLSSON Ulf; PREVOST Sylvain and TORNQUIST Elin. (2018). Understanding bone collagen structure with Small Angle Neutron Scattering. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-05-432
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