The influence of crowding, cosolvents and high pressure on protein dynamics
The enzyme human Butyrylcholinesterase (hBChE) will be investigated in the presence or not of salts and as function of high hydrostatic pressure. The exact effects of lyotropic salts on the structure and dynamics of biological systems is a highly debated question, especially their potential to counteract environmental stresses as pressure. Therefore, we would like to study hBChE under various salt conditions on IN5 and IN13 and conduct molecular dynamics simulations in parallel in order to shed light on the effects of salts of the Hofmeister series on enzymes, water and water-ions interactions. Earlier experiments showed that significant effects can be expected for this enzyme.
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PETERS Judith; CISSE Aline; KOZA Michael Marek; MASSON Patrick; OLLIVIER Jacques and ZELLER Dominik. (2019). The influence of crowding, cosolvents and high pressure on protein dynamics. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-05-440
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