The effect of co-solutes to counteract environmental stress conditions on proteins
The enzyme human Butyrylcholinesterase (hBChE) will be investigated in the presence or not of salts and as function of high hydrostatic pressure. The exact effects of lyotropic salts on the structure and dynamics of biological systems is a highly debated question, especially their potential to counteract environmental stresses as pressure. Therefore, we would like to study hBChE under various salt conditions on IN5 by quasi-elastic neutron scattering and conduct molecular dynamics simulations in parallel in order to shed light on the effects of salts of the Hofmeister series on enzymes, water and water-ions interactions. Earlier experiments showed that significant effects can be expected for this enzyme.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
PETERS Judith; CISSE Aline; KOZA Michael Marek; MASSON Patrick; OLLIVIER Jacques and ZELLER Dominik. (2019). The effect of co-solutes to counteract environmental stress conditions on proteins. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-05-452
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.