Molecular bases of proteome adaptation to high pressure in extremophilic Archaea
In the last years, we studied successfully prokaryotes from the deep sea under high hydrostatic pressure conditions and were able to identify first routes to pressure adaptation in such systems. Now we want to extend the study to proteins extracted from these organisms, which are sufficiently sensitive to pressure to provide answers on how they are thriving with extreme conditions. Dynamics of surrounding water molecules will be included in the study to get an as complete picture as possible about piezophilic proteins, their environment and the effects of temperature and pressure variation on them. We hope to gain more insights on their functionalities and their specific capacities of adaptation, as structural modifications were ruled out to explain them.
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PETERS Judith; Antonino Caliņ; KOZA Michael Marek; Phil Oger and ZANOTTI Jean-Marc. (2020). Molecular bases of proteome adaptation to high pressure in extremophilic Archaea. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-05-458
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