Location of steroidal molecules in monolayers of anionic and cationic surfactant
Many drug molecules are very water-insoluble which limits their commercialisation and use by the patient. Solubilisation in surfactant micelles is an attractive means of increasing the apparent aqueous solubility thereby ensuring their delivery and ultimate use by patients. Surprisingly, however, very little is understood about the relationship between surfactant and drug structure and the micelle's ability to solubilise drugs. As a drug's incorporation into surfactant monolayers mirrors its distribution in surfactant micelles, here we focus on the study of drug distribution into surfactant monolayers. The present study aims to determine the level of incorporation and the extent of penetration of two hydrophobic drugs, 4-cholesten-3-one and testosterone heptanoate into monolayers formed by the surfactants sodium dodecyl sulphate and dodecyltrimethylammonium bromide using neutron reflectivity in combination with contrast variation. The results will be correlated with SANS and MD studies determining the location of the drugs in the surfactant micelles and thereby aid a better understanding of the relationship between surfactant and drug structure and micelle solubilisation capacity.
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M Jayne Lawrence; AL OBAIDI Hisham; BARLOW David J.; Richard A. Campbell; SHAO YANAN and TUMMINO Andrea. (2015). Location of steroidal molecules in monolayers of anionic and cationic surfactant. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1435
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