A new platform of Polymeric Nanocapsules with tunable morphology
Nanocapsules (NCs) are nano-vesicular systems exhibiting a core-shell structure, particularly promising as carriers for drug delivery applications. The drug release profile is correlated to their morphology, particularly their shell thickness. However, very little is known about the detailed microstructure of polymeric NCs, in particular their shell thickness. The aim of this proposal is to elucidate the structure of a novel platform of NCs intended for the delivery of anti-cancer agents. The NCs comprise a biocompatible oily core Miglyol 810, a poly(methyl methacrylate) inner shell and a natural polysaccharide (dextran) as hydrophilic coverage. These have been prepared by the combined use of Miniemulsion polymerisation, Reversible Addition Fragmentation Chain Transfer (RAFT) polymerization and a transurf (both transfer agent and stabilizer during the polymerisation). This unique combination of techniques affords improved control over the NCs morphology. Our objective is to correlate polymerization conditions with structural parameters (oily core size, shell thickness) and, in turn, link these to the release characteristics.
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Dreiss; Laura M. Forero Ramirez; GRILLO Isabelle; NOUVEL Cecile; Ridolfi D M and SIX Jean Luc. (2015). A new platform of Polymeric Nanocapsules with tunable morphology. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1447
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