Effect of surfactant head group onthe location of steroidal drugs into monolayers of surfactant
Many drug molecules are very water insoluble which limits their commercialization and use by patients. Solubilisation in surfactant micelles is an attractive means of increasing the apparent aqueous solubility of a drug and thereby ensuring its successful delivery and ultimate use by patients. Surprisingly, however, very little is known about the relationship between surfactant and drug structure and the micelle's ability to solubilise drugs. As a drug's incorporation into surfactant monolayers mirrors its distribution in surfactant micelles, here focus on the study of drug distribution into surfactant monolayers. The present study aims to determine the level of incorporation and the extent of penetration of 3 hydrophobic steroidal drugs, 4-cholesten-3-one, testosterone enanthate and adrenosterone, into monolayers formed by the surfactant dodecyltrimethylammonium bromide using neutron reflecticity in combination with contrast variation. The results will be correlated with SANS and MD studies determining the location of the drugs in the micelles and thereby aid a better understanding of the relationship between surfactant and drug structure and micelle solubilisation capacity.
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M Jayne Lawrence; Richard A. Campbell; LORUTHAI Orathai and SHAO YANAN. (2016). Effect of surfactant head group onthe location of steroidal drugs into monolayers of surfactant. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1465
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