Squalene Nanomedecine: solvent effect in controlling size and internal structure
Due to the quick adaptation of microorganisms to chemicals and the shrinking range of drugs available, medicine try to find a way to avoid drug resistance and treatment side effects. In 2016 Couvreur et al. discovered a new prodrug molecule, the Squalene-Gemcitabine, able to self-assemble with liquid crystal structure via squalenoylisation: the nucleoside-like is linked with amide bond to a biocompatible fatty acid the squalenic acid. The prodrug is nanoprecipitated via ouzo effect (solvent-antisolvent mixing). Saha et al. have shown that the nature of the solvent plays a key role in structure stability and nanoparticle size. With a SANS comprehensive characterization, we would like to understand the role of the solvent (polarity, viscosity and water coefficient diffusion) on the nanoformation, to further better control the internal structure and the polydispersity of the particles. Two solvents (acetone and DMSO) and 2 molecules (Squalene-Gemcitabine, Squalene-Deoxycytidine) will be used in different concentrations and ratios.
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marret; DEME Bruno; GRILLO Isabelle; MULLER Francois and TESTARD. (2016). Squalene Nanomedecine: solvent effect in controlling size and internal structure. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1485
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