Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions
The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on lipid (fat) digestion. Although the characterisation of BS interfacial behaviour is beginning to garner interest, the structure-function relationships governing their interfacial behaviour remain unknown. Neutron reflectivity (NR) is the only technique which can provide a detailed molecular picture of the BS/lipids interface, over time and at equilibrium. We propose here to measure the interfacial interactions of two distinct BS, sodium taurocholate hydrate (NaTC) and sodium taurodeoxycholate hydrate (NaTDC), with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer, using a Langmuir trough (LT). NR measurements will be employed to obtain information on the organisation of these systems at the air/water interface, monitor changes in the lipid monolayer and establish, with precision, the localisation of each BS at the interface.
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Dreiss; GERELLI YURI; GRILLO Isabelle; Richard D. Harvey; PABOIS Olivia and WILDE Pete. (2017). Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1488
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