Squalene Nanomedecine: solvent and temperature effect in controlling size distribution
Due to the quick adaptation of microorganisms to chemicals and the shrinking range of drugs available, medicine try to find a way to avoid drug resistance and treatment side effects. In 2016, Couvreur et al. discovered a new prodrug family via the squalenoylation of nucleoside analogues. The prodrug was nanoprecipitated via ouzo effect (solvent-antisolvent mixing) leading to nanoparticles with a liquid crystal structure. For squalene-gemcitabine and squalene-deoxycitidine, Saha et al. have shown the key role of the solvent in structure stability and nanoparticle size for naoprecipitation from ethanol. Recently, we found a different behavior when DMSO and acetone are utilized for the nanoprecipitation: Single nucleation and no aggregation was observed with increasing the organic solvent volume fraction. In addition, temperature appeared as very important in the control of polydispersity. With these news results, it becomes crucial to complete our data set with a study on a forth solvent and a more precise quantification of the temperature effect. This is the aim of this proposal (continuation of 9-10-1485) to finally explain the particularities of the squalenoyl NPs formation.
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marret; Frédéric Gobeaux; GRILLO Isabelle; MULLER Francois and TESTARD. (2017). Squalene Nanomedecine: solvent and temperature effect in controlling size distribution. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1502
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