Self-assembled Nanocapsules as Drug Carriers and Artificial Nano-Enzymes
New organic nano-capsules from aggregation of triphenylene units with a hydrophobic core (2.0 nm) and a hydrophilic shell (0.7 nm) hold great potentialities as drug carrier for highly hydrophobic drugs like Nitrofurantoin, Naproxen, Vancomycin and anticancer Doxorubicin. The nano-capsules in water allow to bind hydrophobic substrates and to convert them into valuable products like artificial enzymes for bio-tech applications. We prepared three samples with different hydrophilic shells bearing negative or positive charges or hydrophilic PEG units to show a great complementarity of size and distribution to complement different kind of drugs and substrates. A deep understanding of the aggregation properties is fundamental to tailor their cargo ability towards hydrophobic substrates. We ask for 2 days on D11 in order to use its large Q range and fully investigate the size distributions and the shape of aggregates, to further achieve efficient binding for pharmaceutical and bio-technological applications. We ask 6 days on D16 to investigate the effect of the dilution and the different hydrophilic side chains on the shell corresponding to a change of the bond angles of the tails.
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Alessandro Scarso; BALLESTER Pablo; BONIFAZI Davide; CRISTIGLIO Viviana; MONDELLI Claudia and SCHWEINS Ralf. (2020). Self-assembled Nanocapsules as Drug Carriers and Artificial Nano-Enzymes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1632
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