Protein adsorption and foul resistance of PDMS and amphiphile doped PDMS coatings
As the continuation of a recent, successful study of the surface reconstruction of polydimethlysiloxane (PDMS) coatings in water by the spreading of a layer of amphiphilic perfluoropolyethers (PFPE) we seek further beam time to study the adhesive behaviour and subsequent removal of Proteins on PDMS and PFPE-PEO doped PDMS surfaces in a stop flow experiment. This would be both a novel study of the mechanism of Protein fouling on PDMS via neutron reflectivity and a comparative study assessing how wetting layers of PFPE can improve the foul resistance of PDMS coatings. Through this we would be able to better understand some of the fundamental mechanisms of early biofouling and why some molecules are so effective at resisting this fouling.
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SEXTON Thomas; JONES Richard A.L.; MICCIULLA Samantha; Andrew J. Parnell and SAERBECK Thomas. (2021). Protein adsorption and foul resistance of PDMS and amphiphile doped PDMS coatings. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1661