Defining Short-chain Alcohol Distribution in Phospholipid Multilayers
Phospholipid (PL) liposomes are of central importance for industrial formulations in pharmacology and cosmetics. Typically, they are obtained by injecting a concentrated ethanolic PL solution (or other alcohol) into water with subsequent application of shear to reduce the liposome size and make them colloidally stable. However, it is not clear to which extent do short-chain alcohols behave as cosurfactants nor their definite location in the phospholipid bilayer (despite their miscibility with water). For example, a fast ultrafiltration on a lipid dispersion did not remove any alcohol, whereas doing it over several hours resulted in complete removal of the ethanol. Solvent contrast provided by SANS would be the ideal tool to further study the sturctural changes of fluid bilayers in the presence of short-chain alcohols.
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ALVARADO GALINDO Fernanda; GRADZIELSKI Michael; HOFFMANN Ingo and PREVOST Sylvain. (2021). Defining Short-chain Alcohol Distribution in Phospholipid Multilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1722
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