Ceramide Crystals in Phospholipid Liposomes
Ceramides (CERs) are one of the main lipids in the Stratum Corneum (SC), and play an essential role on the skin¿s barrier function. Damage to the SC either by internal or external stimulus results in lower CER levels and com- promises its barrier properties. A promising therapy is to restore CERs by delivering them into the skin, but its widespread use is limited as current formulations use stabilisers that may cause adverse skin effects. A promising alternative are phospholipid (PL) liposomes as they are established delivery systems in pharmaceutic and cosmetic applications. However, limited colloidal stability caused by CER crystallization is one of the main drawbacks for PL:CER systems. We intend to apply S/WANS and NSE to elucidate the mechanism for the failure of stability of these formulations.
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ALVARADO GALINDO Fernanda; CRISTIGLIO Viviana; GRADZIELSKI Michael; HOFFMANN Ingo; PREVOST Sylvain; SCHMIDT Robert Franz and VENZMER Joachim. (2023). Ceramide Crystals in Phospholipid Liposomes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1738
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