Structure of PLGA nanoparticles for drug delivery to the brain
Biodegradable polymer nanoparticles are a commonly used method for controlled drug release. Recently in collaboration with medics in Bristol, we have studied the feasibility of using PLGA nanoparticles for controlled release of drugs to the brain where the nanoparticles are delivered by injection via convection-enhanced drug delivery through microcatheters. Incorporation of small molecules into the nanoparticles can be hindered by the relatively hydrophobic nature of PLGA so PEG and PEG-lipid conjugates have been introduced into the particles to assist drug/tracer molecule incorporation however the effect on particle nanostructure is not known. Also spreading of the particles into the brain tissue is governed by particle size and charge but recent work has suggested that the particle mass is also important for distribution and persistance of nanoparticles in the brain. Here we propose to use SANS to determine the structure & density of PLGA nanoparticles prepared with or without PEG or lipid via contrast variation. Understanding the particle structure will help to rationalise the location of more hydrophilic species in the particles, to assist understanding the release profiles.
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Karen J Edler; SCHWEINS Ralf; SHIKO Elenica and YANG Bin. (2012). Structure of PLGA nanoparticles for drug delivery to the brain. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-1611
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