Dynamics of hydration water of Hyaluronic Acid
Hyaluronic acid (HA) is one of the most important polysaccharide in biology. It can associate with proteins by specific interactions but also via electrostatic interactions, hydrogen bounding and hydrophobic forces. One important properties of the HA is that its biological functions can be opposite depending on its molecular weight. Like any biological system, its functionality is related to the dynamics of hydration water. With the goal of understanding the mechanisms followed by this versatile biopolymer and in particular the effect of the chain length, we propose to continue the characterization of the dynamics of its hydration water by elastic incoherent neutron scattering. We already investigated 2 hydration rates for a long chain HA sample, in H2O, in D2O and in the dry state. The characterization of the influence water has on the dynamical transition is under investigation. We would like with this proposal to complete our data by measuring another (a second) HA mass in the same hydration conditions, in order to study the possible relation between their biological opposite functions and the hydration properties. The time required for such an experiment will be 7 days on IN13.
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MORFIN Isabelle; COMBET Jerome; GRILLO Isabelle; PETERS Judith; PLAZANET Marie; SPAGNOLI Sylvie and ZELLER Dominik. (2016). Dynamics of hydration water of Hyaluronic Acid. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-1771
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