Experiment title: Dynamics of hydration water of hyaluronic acid / ionic surfactant complexes
Hyaluronic acid (HA) is one of the most important polysaccharide in biology. It is often associated with proteins (or other molecules) by specific interactions but also via electrostatic interactions, hydrogen bounding and hydrophobic forces. One important property of the HA is that its biological function can be opposite depending on its molecular weight and like any biological system, its functionality is related to the dynamics of hydration water. We already investigated the water dynamics of 2 hydration rates for long and short chain HA samples, in pure H2O, pure D2O and in the dry state. With the goal of understanding the mechanisms followed by this versatile biopolymer and in particular the associations effects, we propose to continue the characterization of the dynamics of its hydration water by elastic incoherent neutron scattering on purely electrostatic HA complexes. HA/ionic surfactants forming complexes that we observed by SANS in more dilute solutions will be used. For such experiments, the same hydration conditions as for HA solutions previously studied on IN13 will be considered, in order to investigate the effect of the complexation on the HA hydration properties.
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MORFIN Isabelle; COMBET Jerome; GRILLO Isabelle; NATALI Francesca; PETERS Judith; PLAZANET Marie and SPAGNOLI Sylvie. (2018). Experiment title: Dynamics of hydration water of hyaluronic acid / ionic surfactant complexes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-1836
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