Understanding aggregation in drug-conjugate gels
Gels can be used for drug delivery as carriers for an encapsulated drug. An alternative approach is to make the actual gel matrix itself from the drug. As the gel breaks down, the drug is released. This allows a slow release, and also the gel can be used to fill space for example in invasive brain surgery. For this to work, it is necessary to build gels from drug-conjugates. These need to have the right self-assembled morphology to form a gel and also such that the degradation rate is correct. We have found that we can control the gel properties and degradation rate by functionalising a drug with a dipeptide; different properties can be tuned by the choice of dipeptide and (critically) the chirality. To tune and develop our systems, we need to link our data to the self-assembled structures which we will determine using SANS.
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ADAMS Dave; Emily R. Draper and SCHWEINS Ralf. (2019). Understanding aggregation in drug-conjugate gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-1905
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