DOI > 10.5291/ILL-DATA.9-11-1931

This proposal is publicly available since 02/01/2025

Title

Self-assembled stimuli-responsive polymersomes loaded with doxorubicin for tumor drug delivery

Abstract

The main aim of this proposal is to determine the influence of the pH on doxorubicin (DOX) partition between the aqueous phase and the hydrophobic membrane of the vesicle during the polymersomes preparation by microfluidic nanoprecipiation which is of fundamental importance on the control of the DOX loading process into polymersomes.

Experimental Report

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Data Citation

The recommended format for citing this dataset in a research publication is in the following format:

STEPANEK Petr; BABUKA David; JAGER Alessandro; JAGER Eliezer; SCHWEINS Ralf and STEINHART Milos. (2020). Self-assembled stimuli-responsive polymersomes loaded with doxorubicin for tumor drug delivery. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-1931

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Metadata

Experiment Parameters

  • Environment temperature

    20 to 50 deg C

  • Experiment energy

    6 to 12 A

  • Experiment moment

    ~1E-3 to 0.1 1/A

  • Experiment res energy

    9%

  • Experiment res moment

    standard

Sample Parameters

  • Formula

    • doxorubicine in H2O/D2O
    • poly([N-(2-hydroxypropyl)] methacrylamide)-bpoly[ 4-(aminophenylboronic pinacol ester)methacrylate] in D2O+H2O
    • poly([N-(2-hydroxypropyl)] methacrylamide)-b-poly[2-( 2-(4-isopropylphenyl)aceta mido)ethyl methacrylate] in D2O/H2O
    • poly([N-(2-hydroxypropyl)] methacrylamide)-bpoly[ 4-(ethyl-phenylboronic pinacol ester)methacrylate] in D2O/H2O
    • poly([N-(2-hydroxypropyl)] methacrylamide)-b-poly[2-( diisopropylamino)ethyl methacrylate] in D2O/H2O

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