Self-assembly of films from pharmaceutically acceptable components at the air-water interface
In this proposal we wish to further our studies of mesostructured films which form spontaneously at the air-solution interface on solutions of mixed surfactants. Here we wish to study two systems that will progress our understanding of film formation and our ability to prepare films from pharmaceutically acceptable components for drug delivery applications. We will first study the structure, and structure development in several new formulations consisting of pharmaceutical polymers, structured using orally acceptable surfactants, and second we will study the composition and structure of films formed on octylglucoside/DMPC mixtures where, on the basis of previous work, we have predicted the gradient in structure and composition at the interface. Selective deuteration and neutron reflectivity will provide unique insights into the structure and composition of these films, allowing future development of novel and sophisticated drug delivery systems.
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Karen J Edler; Jenny Marie Andersson; BARROS Joao; Richard A. Campbell; EDWARDS Alexander; ROGER Kevin and SPARR Emma. (2014). Self-assembly of films from pharmaceutically acceptable components at the air-water interface. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-351
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