Detection of nano-rafts in hybrid lipo-polymersomes
Hybrid vesicles made by the self-assembly of both amphiphilic copolymers and phospholipids attracted a lot of interest in the last years. Such assemblies are more advanced vesicular structures than their liposome and polymersome forerunners, as the best from the two systems is integrated in a single hybrid vesicle. They could be used as nano-reactors for enzymatic reactions or artificial biological cell membrane mimics. But the mechanisms governing phase-separation of the membrane into domains analogous to lipid rafts in cells are not known. For giant vesicles (GUV) observed by microscopy, hybrid vesicles either homogeneous (at least at the micrometer scale) or presenting micrometric domains can be obtained, depending on the two control parameters which are: the lipid/polymer ratio and the temperature relatively to the melting temperature (Tm) of lipids. However, no information is available in literature about the membrane structure of lipid/polymer hybrid small unilamellar vesicles (SUV). We aim to elucidate the effects of lipid fluidity, copolymer architecture and block length on the membrane structure of hybrid SUVs and to correlate them with the membrane structure seen on GUVs.
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SANDRE Olivier; BRULET Annie; DAO Thi Phuong Tuyen; LE MEINS Jean Francois; LECOMMANDOUX Sebastien; PRIETO Manuel and SCHWEINS Ralf. (2014). Detection of nano-rafts in hybrid lipo-polymersomes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-357
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