Interaction between functionalized Fe3O4 nanoparticles and lipid bilayers
Recently Fe3O4 nanoparticles have been introduced as novel contrast agents for Magnetic Resonance Imaging (MRI) technique, with the potentiality of being at same time nanocarriers for drugs. However, there are still several concerns about nanoparticle biocompatibility, which is essential for both the application as contrast agents and drug delivery devices. Thus, we introduced a novel nanoparticle functionalization approach, based on the use of phospholipids, aiming to produce biocompatible functionalized Fe3O4 nanoparticles. In the process of the development of a biocompatible nanostructured system, it is important to consider how it interacts with the most external cellular component, the cellular membrane. With this focus, we propose Neutron Reflectivity (NR) measurements to study the interaction of functionalized Fe3O4 nanoparticles and lipid bilayers that will simulate a biological membrane. In the presence of interaction, the stability of the membrane with time will be evaluated. Finally, the interaction site within the membrane bilayer will be determined.
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LUCHINI Alessandra; FRAGNETO Giovanna; GERELLI YURI; PADUANO Luigi and VITIELLO Giuseppe. (2015). Interaction between functionalized Fe3O4 nanoparticles and lipid bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-367
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