Formation of pluronic micellar clusters induced by the change of chain conformation of hyaluronic acid after addition of salt
The structure of complexes formed between nonionic surfactants and polyelectrolytes as well as the nature of the interactions are still discussed in literature. We work with the F127 Pluronic, a nonionic triblock copolymer and hyaluronan (HA), a linear semirigid polyelectrolyte. A first SANS experiment has evidenced the formation of small micelle cluster after addition of NaCl (0.1M) which induces the change of conformation of the polyelectrolyte chain. We propose to continue the SANS characterization by varying the nature of the salt, the salt concentration and the temperature in order to evidence the nature of the forces involved in the complex formation. In addition, such mixed system has a potential application for drug encapsulation and delivery. F127 is biocompatible and form micelles of ca. 200 Å, a perfectly adequate size for pharmaceutical applications. HA is currently investigated as a target-specific material because many malignant cancer cells overexpress HA receptors such as cluster determinant 44 (CD44) and thus incorporation or conjugation of HA can be used as targeting ligand.
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GRILLO Isabelle; COMBET Jerome and MORFIN Isabelle. (2015). Formation of pluronic micellar clusters induced by the change of chain conformation of hyaluronic acid after addition of salt. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-417
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