Revealing the dynamics of phosphocholine molecules on SPION surface
SuperParamagnetic Iron Oxide Nanoparticles (SPIONs) contrast agents for Magnetic Resonance Imaging (MRI) technique as well as potential nanoplatforms for drug delivery. Recently we have developed a functionalization protocol based on hydrophobic interaction, which leads to the SPIONs coating with amphiphilic molecules such as, 1-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine (18LPC). 18LPC/SPIONs were indeed demonstrated to be stable in water suspension and biocompatible. The interesting feature of 18LPC/SPIONs is that two layers of amphiphilic molecules, one composed by oleic acid and oleylamine (stabilizing agents during nanoparticle synthesis) and the second one composed by 18LPC, are present on the SPION surface. The dynamics of the two amphiphilic layers coating the SPIONs surface represent important variables in determining the nanoparticle stability toward aggregation processes, their interaction with biological system, such as cellular membrane, and possible complexation with small molecules such as drugs. For these reasons, here we propose to perform Quasi-Elastic Neutron Scattering (QENS) measurements on 18LPC/SPIONs using 18LPC micelle suspension as reference.
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LUCHINI Alessandra; OLLIVIER Jacques; Alessandro Paciaroni; PADUANO Luigi; PERFETTI Marco and VITIELLO Giuseppe. (2016). Revealing the dynamics of phosphocholine molecules on SPION surface. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-440
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