Nucleation Kinetics and Growth of Poorly Water-Soluble Fenofibrate Drug Nanoparticles
Precipitation is an established and nowadays widely used bottom-up approach for the production of nanosuspensions of poorly water-soluble active pharmaceutical ingredients. To enhance their bioavailability, suitable stabilizers have to be selected to inhibit agglomeration in order to produce smaller particles. The purpose of the proposed experiment is to study the influence of three structurally different polymeric stabilizers (HPC, HPMC, poloxamer 188) on the nucleation kinetics and growth of organic drug nanoparticles prepared by precipitation. We will use fenofibrate as a model system, since reliable stabilizers are well known as a result of preliminary precipitation as well as media milling experiments and its formation kinetics take place on a time range well suitable for the stopped-flow method. The SANS measurements will be complemented by own SAXS measurements. Assuming a time of over 17 h only for the high amount of mixing processes needed for one of three proposed sample systems, adding the time needed for the high amount of manual refillings and regarding calibration, background and transmission measurements, we apply for three days of beamtime at the D22 instrument.
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NOLL Dennis; HEPPT Jano; PORCAR Lionel; SCHINDLER Torben; SCHULDES Isabel and UNRUH Tobias. (2016). Nucleation Kinetics and Growth of Poorly Water-Soluble Fenofibrate Drug Nanoparticles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-476
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