Biofriendly Multilamellar Vesicles (MLVs) Controlled by Admixing Modified Chitosan
By the addition of chitosan one can control the number of shells in multilamellar vesicles (MLVs) of alkylethoxycarboxylates, which are mild surfactants. However, due to the solubility of chitosan this is only possible at lower pH. In the planned experiments this pH range therefore is to be extended by the use of quaternized chitosan, which is soluble at any pH. By a systematic variation of pH, mixing ratio, degree of quaternization and type of vesicle forming surfactant, we want to gain a comprehensive picture of the MLVs formed in these systems. This can be achieved in a unique fashion by SANS and then allows to have predictive power over the behaviour of such systems. This is highly important as via the number of shells and the thickness of the single bilayers one should be able to control in a systematic fashion the permeability of the MLVs, which is a key property for their use as delivery systems. As such they are highly interesting as they have strongly pH dependent properties and thereby can be triggered by pH on demand, once their structures are known, which is the key aim of this proposal.
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GRADZIELSKI Michael; Leonardo Chiappisi; DAI Bin; GRUNERT Wiebke; HOERMANN Anja and SCHWEINS Ralf. (2018). Biofriendly Multilamellar Vesicles (MLVs) Controlled by Admixing Modified Chitosan. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-490
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