Tuning Electrostatic Interactions in Uncommon Structures in Hyaluronate/Surfactant Complexes
In polyelectrolyte/surfactant complexes (PESCs) of hyaluronic acid (HA) and cationic surfactant tetradecyltrimethylammonium bromide (TTAB) we have observed the formation of rather large aggregates of low density, that remain constant in structure over a large range of charge ratios. By introducing tetradecyldimethylamine oxide (TDMAO), a nonionic surfactant that otherwise structurally resembles TTAB, into the system, we are able to vary the charge density of the micelles without changing their structure. This allows us to alter the charge conditions in the aggregate, which should have a strong impact on their structure, as experiments with a related system have shown. Additionally, varying the ionic strength allows us to tune electrostatic interactions, which gives us two additional parameters to shine light on the forces that guide the formation of these fascinating complexes. This SANS/LS-study will deliver the structural details for the assembly conditions in this new type of PESCs. This is of fundamental interest, of relevance for biomedical applications because of the rich abundance of HA in the human body, and finally gives structural control over this novel type of PESC.
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BAYER Sebastian; AZERI Ozge; GRADZIELSKI Michael; PRAUSE Albert; SCHWEINS Ralf and SIMON Miriam. (2019). Tuning Electrostatic Interactions in Uncommon Structures in Hyaluronate/Surfactant Complexes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-545
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