Interaction of non-ionic alternating amphiphilic polymers with lipid membrane - SANS
We found that non-ionic alternating amphiphilic co-polymers (NAAPs) with a balanced amphiphilicity can passively translocate through lipid bilayers without damaging the membrane. The translocation through lipid bilayers is currently investigated by PFG NMR and fluorescent microscopy. We found that it consists of a relatively fast membrane saturation with the polymers and a slow release process. We would like to use SANS to study the structural changes of the lipid bilayer caused by the NAAPs. A comparison of the different NAAP compositions and molecular weight will allow us to obtain information about the polymer-lipid interaction and the translocation mechanism.
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KOSTYURINA Ekaterina; ALLGAIER Juergen; BIEHL Ralf; CUBITT Robert; Henrich Frielinghaus; KRUTEVA Margarita and PREVOST Sylvain. (2021). Interaction of non-ionic alternating amphiphilic polymers with lipid membrane - SANS. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-641
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