Assessing how hydrophilic quantum dots alter the organization of charged lipid bilayers
Quantum dots (QDs) are semiconductor nanoparticles with unique optical and electronic properties, with increasing interest as potential nano-theranostic platforms for imaging and sensing. The design and use of QDs requires the understanding of cell-nanoparticle interactions at the molecular level, which depends on surface charge of both membranes and the nanomaterials, and plays a important role in early-stage nanoparticle uptake driven by long-range electrostatic interactions. Conflicting results on how surface charge affects the efficiency of nanoparticles membrane disruption and cellular uptake have been reported due to the complexity of the cell constituents and environment used in nanoparticle-cell interactions experiments. Motivated by this controversy, we propose the use of neutron reflectometry and small angle neutron scattering to study the interactions between charged artificial lipid bilayers and QDs. Combining well-controlled lipid bilayer model systems with robust time-resolved structural characterization techniques we aim at dissecting the role of charge on nanoparticle-lipid bilayer interactions and assessing the probability of insertion and bilayer disruption.
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LOSADA PEREZ Patricia; BAR Laure; GERELLI YURI; GUTFREUND Philipp; Ben Humphreys; Nicoḷ Paracini; PORCAR Lionel and VILLANUEVA Martín Eduardo. (2023). Assessing how hydrophilic quantum dots alter the organization of charged lipid bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-696
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