Lipoprotein capacity to exchange lipids from normo- and hyper- trigliceridemic individuals or presenting lipoprotein(a)
The complexity of lipoprotein composition makes it very difficult to map out its role on atherosclerosis development and contradictory results are found in the literature. Not only there are differences in terms of apolipoproteins present in the different lipoprotein classes but also the type of lipids and the proportion between them. Neutron reflection excels at determining the lipoprotein capacity to exchange fats and the exchange results so far mirror clinical data suggesting this model system can be used to explore the function of lipoproteins versus composition. So far we have used pooled samples from healthy adult males but now we are ready to look at differences between individuals with distinctive lipid profiles. In this proposal we aim at finding whether there are differences in lipid exchange between lipoproteins from individuals with normo- and hypertriglyceridemic profiles with or without the presence of lipoprotein(a), a known marker for atherosclerosis. These results will advance our understanding on atherosclerosis development, which is the main killer in the west.
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CARDENAS; Yubexi Correa; FRAGNETO Giovanna; GERELLI YURI; JANSEN Martin; SAERBECK Thomas; SEBASTIANI Federica and Sarah Waldie. (2021). Lipoprotein capacity to exchange lipids from normo- and hyper- trigliceridemic individuals or presenting lipoprotein(a). Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1000
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