Probing photoswitching in lipid vesicles using small-angle neutron scattering
As with cell membranes where the transport of materials in and out is controlled by specific channels, changing the porosity of vesicles can be exploited for controlled release of drugs in medical treatments. This proposal concerns a photoswitchable system. SANS with hydrogen/deuterium contrast variation will be used to study a model system consisting of an azobenzene-glycolipid in phospholipid (DPPC) vesicles. We will first determine the localization of the amphiphilic glycolipid within the phospholipid bilayer, and then probe whether the structural changes upon photo-switching with UV and blue light, which induce changes in the orientation azobenzene-glycolipid, cause reorientation of the DPPC head or tail-group, or a combination of both. The fundamental understanding gained in this work will guide future practical developments.
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ARNOLD Tom; Judith E. Houston; HOVELMANN Svenja; B. M. Murphy; PREVOST Sylvain; RENNIE Adrian R. and SCHWEINS Ralf. (2021). Probing photoswitching in lipid vesicles using small-angle neutron scattering. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1026
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