Fate of Enkephalin¿based nanomedicines and stability in protein solutions: different surface charges to investigate the protein adsorption.
To face the global health challenges of new pain killer, an efficient pharmacologically efficient nanomedecine based on nanoparticles (NPs) suspension was developed. The NPs are formed by nanoprecipitation of a bioconjugate (LENK-SQ) obtained by a versatile linkage between squalene (SQ) and the otherwise metabolized Leu-enkephalin (LENK) neuropeptide. Three type of linkage (amide, dioxycarbonyl or diglycolic spacer) have been explored to ensure the formation of NPs with similar composition but different surface charges. For these three bioconjugates, no evident relation have been found between their in vivo analgesic profile after intravenous injection and their chemical stability and release profil of the LENK in mouse serum. To help the understanding of these NPs bio-activity, the aim of this proposal is to investigate the protein corona formation around these organic nanoparticles with different surface charges using model system for the proteins (BSA and hemoglobin). Beyond this particular system, we hope with this study to give a better description of corona protein around deformable organic Nps.
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TESTARD; Frédéric Gobeaux; LEPETRE-MOUELHI Sinda; MARTEL Anne; PIN SERGE and Jean-Philippe Renault. (2021). Fate of Enkephalin¿based nanomedicines and stability in protein solutions: different surface charges to investigate the protein adsorption.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1028
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