Impact of Hyaluronic Acid and Polymeric Analogues on the Mechanics of Lipid Oligobilayers Studied by Off-Specular Neutron Scattering
The main component of synovial fluid is negatively charged hyaluronic acid (HA). Together with oligolamellar lipid bilayers, which cover the cartilage in mammalian joints, it contributes to joint lubrication. Using specular neutron reflectometry and infrared spectroscopy we have already shown that contact with aqueous solutions of HA significantly improves the shear stability of the lipid layers. The same effect is observed upon exposure to aqueous solutions of positively charged poly(allylamine hydrochloride) (PAH) with the advantage of much shorter equilibration times. The degree of stability depends both on the molecular weight and type of polymer. Therefore, we now want to unravel the impact of HA and PAH on the mechanical properties of the lipid layers utilizing off-specular neutron scattering, and correlate the extracted vertical compression modulus and bending rigidity with the observed shear stability.
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DAHINT Reiner; ABUILLAN Wasim; BUSCH Christian and DEME Bruno. (2021). Impact of Hyaluronic Acid and Polymeric Analogues on the Mechanics of Lipid Oligobilayers Studied by Off-Specular Neutron Scattering. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1031
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