Contrast variation studies of protein/polyelectrolyte complexes with encapsulated drug
The main goal of our proposal is to use the contrast matching technique for small-angle neutron scattering (SANS) measurements to reveal morphology of complexes formed by the assembly of proteins with diblock copolymers composed of a neutral hydrophilic block and a polycationic block and the effect of encapsulation of an ionic low-molar mass drug into the complexes on their internal structure. Polymer/protein assemblies can be used for targeted delivery and controlled encapsulation/release of both proteins and low-molar mass drugs. The goal of our study is to reveal the effect of protein's nature and drug loading on the morphology of the complexes formed by poly(ethylene oxide)-block-poly(dimethylaminoethyl methacrylate) copolymer and glucagon, insulin or myoglobin with and without encapsulated protoporphyrin-IX by masking various components that is possible thanks to the large differences in their scattering length density (SLD) values for neutrons.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
MURMILIUK Anastasiia; FILIPPOV Sergey; Henrich Frielinghaus; RADULESCU Aurel and SCHWEINS Ralf. (2021). Contrast variation studies of protein/polyelectrolyte complexes with encapsulated drug. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1033
This data is not yet public
This data is not yet public
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.