Configurations of Zwitterionic, Cationic and Nonionic Surfactants in Model Stratum Corneum Membrane Studied by Neutron Diffraction
Surfactant is widely used as drug carrier and penetration enhancer due to the amphiphilic property and self-assembly ability. The hydrophobic interaction between the surfactant tail and lipid layers has been accepted to perturb the hydration layer and lipid packing in SC, which enhances the skin permeability. However, how the surfactant interacts with model lipid membrane, especially with its SPP layers, is still not clear yet. In this proposal, the interaction of cationic surfactant, nonionic surfactant and zwitterionic surfactant with model SC membranes is investigated by neutron diffraction to reveal the difference between surfactant types.
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Yao Chen; DEME Bruno; LI Peixun; LI Zongyi; Mingrui Liao; Jian Ren Lu and ZHUANG ZEYUAN. (2021). Configurations of Zwitterionic, Cationic and Nonionic Surfactants in Model Stratum Corneum Membrane Studied by Neutron Diffraction. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1035
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