Multimodal tools to resolve assembly mechanisms in biological processes: Silks as a model
Due to the inherent chemical and structural complexities of biological processes, the simultaneous combination of several techniques is necessary to gain the desired information about the mechanism and molecular basis for fibril/fibre assembly. It is, therefore, our aim, using our promising NUrF (Neutron small-angle scattering ¿ UV-visible - Fluorescence) platform, to uniquely extract the rate laws and resolve the intermediates involved in the formation of silk protein fibrils. A correct description of the rate laws and individual intermediates will provide new insights in molecular regulation, transient interactions and solvation involved in the supramolecular assembly of fibre forming proteins.
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DICKO Cedric; FRANCIS Juanita; Judith E. Houston; JACKSON Andrew; Gudrun Lotze; MARTEL Anne; PORCAR Lionel; ROOSEN RUNGE Felix and Andrea Scotti. (2021). Multimodal tools to resolve assembly mechanisms in biological processes: Silks as a model. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1036
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